Sundial Initiative is a California nonprofit building scientific infrastructure at the intersection of biological aging, human resilience genetics, and real-world lifestyle data.
We study biology to understand resilience and improve health.
Aging unfolds through the interplay of biological time, biological capacity, and the rhythms of everyday life. Genetic resilience sets a baseline. Daily patterns — sleep, metabolism, behavior, stress — shape whether that resilience is preserved or gradually eroded. SDI studies these interactions longitudinally to identify protective biological programs that support sustained function across the lifespan.
We integrate aging clocks with longitudinal biomarkers to track how biology shifts over time, looking for early signals that emerge before disease becomes clinically visible.
Longevity-associated genetic variants offer windows into protective biological programs. We treat these as guides to what sustained health looks like when biology is working well across the full lifespan.
Genetic and biomarker insights matter only when they connect to how people actually live. We anchor our science within real-world sleep, metabolic, and behavioral patterns.
SDI operates as a science-to-society platform, connecting research, education, and community. Our programs span data infrastructure, biomarker translation, scholar development, and ecosystem building.
A regional aging biomarker and lifestyle database supporting research on biological aging and resilience, and the translation of biomarker insights into public health contexts.
Data infrastructureWe bridge the gap between laboratory aging research and real-world understanding by developing frameworks to interpret aging biomarkers and improving aging literacy for students, clinicians, and the public.
Science translationAn educational pipeline supporting the next generation of aging researchers through research exposure, scientific mentorship, and early career development in biomarker science and longevity biology.
EducationSDI connects research laboratories, clinical partners, and educational programs to create an integrated ecosystem that accelerates the flow of knowledge between science, healthcare, and learning environments.
EcosystemA longitudinal research initiative examining how aging trajectories, genetic resilience variants, and daily behavioral rhythms interact within Pan-Asian populations. The study integrates aging clock data with lifestyle measures to identify early, modifiable signals of declining healthspan that remain invisible to traditional clinical approaches.
The cohort draws on population-specific longevity genetics alongside real-world data on sleep regularity, circadian alignment, and metabolic stability to map the conditions under which biological resilience is maintained, amplified, or lost over time.
Illustrative aging biomarker profile
Illustrative values only. The cohort study will develop population-referenced frameworks for interpreting biomarker profiles over time.
Next BioLeader is SDI's educational pipeline for the next generation of aging scientists. The program provides research exposure, one-on-one scientific mentorship, and early career development in biomarker science and longevity biology — giving students the foundation to lead in aging research.
From high school to early graduate level, Next BioLeader connects emerging scientists with real research questions, experienced mentors, and a community committed to extending human healthspan.
Visit the BioLeader site →SDI is a platform where aging science connects to society. We serve as a science-to-society bridge, transforming data into knowledge, knowledge into education, and education into long-term impact.
SDI is governed by an interdisciplinary team spanning aging science, clinical medicine, policy, and innovation translation.
President & Board Chair
Andy Tsai
Treasurer
Billy Huang
Secretary
Peter Lin
Director, IP & Innovation
Jheel Patel
Program & Education Director
Alena Smith
Next BioLeader
Clinical & Medical Advisor
Hans Chiang, MD, MBA
FACP
Aging is not inevitable decline — it is a biological process we can study, understand, and ultimately reshape. Your support funds the research infrastructure, scientific mentorship, and public education that make that possible.
Support longitudinal studies and biomarker science that reveal how resilience is maintained — or lost — over time across populations.
Fund mentorship, research exposure, and early career development for emerging scientists through the Next BioLeader Scholars Program.
Help translate complex aging biology into knowledge that clinicians, educators, and communities can act on — before decline begins.
Sundial Initiative is a 501(c)(3) California nonprofit.
All contributions are tax-deductible to the extent permitted by law.
"Time is not an inevitable driver of decline. It is a dimension that can be understood, aligned, and leveraged in support of long-term health."Sundial Initiative · Mission Statement